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KMID : 0981820080280040262
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Korean Journal of Laboratory Medicine
2008 Volume.28 No. 4 p.262 ~ p.266
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Tetrasomy 8 in a Patient with Acute Monoblastic Leukemia
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Kim Ju-Won
Song Jae-Woo
Cheong June-Won
Choi Jong-Rak
Lee Sang-Guk
Lee Kyung-A
Park Tae-Sung
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Abstract
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Trisomy 8 is one of the most frequent numerical chromosomal abnormalities observed in hematological malignancies, whereas tetrasomy 8 is a clonal aberration seen mainly in myeloid disorders such as acute myelod leukemia (AML) and myelodysplastic syndromes. In contrast to trisomy 8, tetrasomy 8 is a rare chromosomal aberration, in that only 17 reported AML cases with isolated tetrasomy 8 have been documented. Interestingly, the majority of reported cases were associated with monocytic-lineage leukemias. According to recent reports, tetrasomy 8 is regarded as a poor prognostic
factor, and most patients having this abnormality relapsed and died within 1 yr. Here, we report a patient with acute monoblastic leukemia having tetrasomy 8 and a very aggressive disease course.
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KEYWORD
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Acute myelogenous leukemia, Tetrasomy 8, Poor prognosis
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